Questions about replacing SEP 12.1.x / SSR 2011 PCs with SEP.cloud / SSR 2013

At a client site, the computers have SEP 12.1.4 installed with SSR 2011 (as part of the Symantec Protection Suite 4.x).

To reduce overhead and file churn on the server, I plan to remove all of the SEP 12.1.4 clients on the computers, and SEPM on the server - and replace all with SEP.cloud.

I am also going to upgrade SSR 2011 to SSR 2013 on the desktops.

I don't see any documentation that discusses this kind of upgrade, so I have some questions.

I know from prior experience that SEP.cloud won't install easily/properly unless the computer is complete clean from prior AV/IS installations.

1.  Is a manual uninstall sufficient for this or do I have to run cleanwipe?

2.  Will something like cleanwipe adversely affect SSR?

3.  Is there a techdoc that describes how to manually remove all traces?

Thanks!