A. Take a Backup of Database OR Follow the Disaster Recovery Steps for 12.1
http://www.symantec.com/docs/TECH160736
B. Symantec Endpoint Protection – How to cleanup excessive disk usage
This document describes the necessary steps required to clean up the content of the folder C:\Program Files\Symantec\Symantec Endpoint Protection Manager\Inetpub\content\
and : C:\Program Files\Symantec\Symantec Endpoint Protection Manager\data\outbox\ImportPackage
1. Stop the Service Endpoint Protection services
start -> run -> services.msc
Symantec Embedded Database
Symantec Endpoint Protection
Symantec Endpoint Protection Manager
Symantec Event Manager
Symantec Management Client
Symantec Settings Manager
2.
>Navigate to the folder C:\Program Files\Symantec\Symantec Endpoint Protection Manager\Inetpub\content\ and then from each of the folders present under the CONTENT folder, go in and delete ALL the sub-folders with names in DIGITS.
>Go to: C:\Program Files\Symantec\Symantec Endpoint Protection Manager\data\outbox\ImportPackage
3. At the END of the file C:\Program Files\Symantec\Symantec Endpoint Protection Manager\tomcat\etc\conf.properties add:
scm.lucontentcleanup.threshold=x (preferably between 1 to 5, since 10 is the default value).
4. Start all services stopped at the step 1.