SEP GUP is not getting update from SEPM

Hi,

I have one SEPM server and approx 1200 GUP at different locations. GUP and clients were taking update from SEPM server.

But some GUP and there clients stopped getting update from SEPM server.

There is no issue of connectivity between Client and GUP, GUP and SEPM and Client and SEPM.

Regards

Pankaj