Clients are not communicating to the manager

Newly installed symantec clients - version 12.1.4 a

clients are not connecting - 

Sylink monitor log : 

05/06 09:33:38.916 [4524] <SendRegistrationRequest:>http://VSEPAPPPV01:8014
05/06 09:33:40.010 [4524] <SendRegistrationRequest:>SMS return=500
05/06 09:33:40.010 [4524] <ParseHTTPStatusCode:>500=>500 INTERNAL SERVER ERROR
05/06 09:33:40.010 [4524] <SendRegistrationRequest:>Content Lenght => 538
05/06 09:33:40.010 [4524] HTTP returns status code=500
05/06 09:33:40.010 [4524] <SendRegistrationRequest:>RECEIVE STAGE COMPLETED
05/06 09:33:40.010 [4524] <SendRegistrationRequest:>COMPLETED, returned 5

Secars test came OK.